Current recommended AIX 5.3 Performance Parameters

Network
no -p -o rfc1323=1
no -p -o sb_max=1310720
no -p -o tcp_sendspace=262144
no -p -o tcp_recvspace=262144
no -p -o udp_sendspace=65536
no -p -o udp_recvspace=655360
nfso -p -o rfc_1323=1
nfso -p -o nfs_socketsize=60000
nfso -p -o nfs_tcp_socketsize=600000

Memory Settings
vmo -p -o minperm%=5
Leave maxperm and maxclient at default of 80
Leave strict_maxperm and strict_maxclient at their defaults
vmo -p -o minfree=960
vmo -p -o maxfree=1088
vmo -p -o lru_file_repage=0
vmo -p -o lru_poll_interval=10

IO Settings
Leave mipgahead and J2_minPageReadAhead at their defaults of 2
ioo -p -o j2_maxPageReadAhead=128
ioo -p -o maxpgahead=16
ioo -p -o j2_maxRandomWrite=32
ioo -p -o maxrandwrt=32
ioo -p -o j2_nBufferPerPagerDevice=1024
ioo -p -o pv_min_pbuf=1024
ioo -p -o numfsbufs=2048

If doing lots of raw I/O you may want to change lvm_bufcnt
Default is 9
ioo -p -o lvm_bufcnt=12

Others left to default that you may want to tweak include:
ioo -p -o numclust=1
ioo -p -o j2_nRandomCluster=0
ioo -p -o j2_nPagesPerWriteBehindCluster=32


Tuning a Perfect Note (Jaqui Lynch)
http://www.circle4.com/jaqui/eserver/eserver-AugSep06-AIXPerformance.pdf